Anti-CD2 monoclonal antibodies prevent the induction of experimental autoimmune myocarditis

T Inomata, T Watanabe, M Haga, H Hirahara… - Japanese heart …, 2000 - jstage.jst.go.jp
… Most organ specific autoimmune disease models induced by immunization with self-… In this
study, we demonstrated that antiCD2 mAb OX34 completely prevented the induction of EAM. …

Immune tolerance to cardiac myosin induced by anti-CD4 monoclonal antibody in autoimmune myocarditis rats

W Qing-Qing, W Yu-Lin, Y Hai-Tao, L Feng-Qin… - Journal of Clinical …, 2006 - Springer
… anti-CD4 monoclonal antibody could induce immune tolerance … tolerance could protect rats
with autoimmune myocarditis from … myosin to induce experimental autoimmune myocarditis. …

Increased expression of CCR5 in experimental autoimmune myocarditis and reduced severity induced by anti-CCR5 monoclonal antibody

X Gong, H Feng, S Zhang, Y Yu, J Li, J Wang… - Journal of molecular and …, 2007 - Elsevier
… for autoimmune myocarditis. We investigated the role of CCR5 in the formation of experimental
autoimmune myocarditis… the activity of CCR5 and prevented Th 1 cells from attending the …

Mononuclear cell secretome protects from experimental autoimmune myocarditis

K Hoetzenecker, M Zimmermann… - European heart …, 2015 - academic.oup.com
… of CD4+ cells effectively prevents disease development. … Experimental autoimmune myocarditis
was induced in 6–8-… following fluorescence-labelled monoclonal antibodies: fluorescein …

Autoimmune myocarditis: treatment with anti-T-cell antibodies

ZT Bilinska, W Ruzyllo - Immune Dysfunction and …, 2008 - Wiley Online Library
Experimental autoimmune myocarditis is a Tcell-mediated … AntiCD2 monoclonal
antibodies were reported to be effective in preventing the induction of experimental autoimmune

Pathophysiology of viral myocarditis: the role of humoral immune response

B Maisch, AD Ristić, G Hufnagel, S Pankuweit - Cardiovascular Pathology, 2002 - Elsevier
… the prevention of experimental autoimmune myocarditis by administering the anti-CD2
monoclonal antibody OX34 resulted from partial T-cell depletion during the induction phase, and …

Monoclonal antibodies generated by DNA immunization recognize CD2 from a broad range of primates

JL Brady, SI Mannering, S Kireta… - Immunology and cell …, 2009 - Wiley Online Library
… For example, anti-CD2 can enhance the activation induced … , prevention of experimental
autoimmune myocarditis in rats … 48 h in the presence of anti-CD2 monoclonal antibodies (mAb), …

[HTML][HTML] Manipulating T cell-mediated pathology: targets and functions of monoclonal antibody immunotherapy

A Martin, RM Tisch, DR Getts - Clinical immunology, 2013 - Elsevier
… of autoimmunity (uveitis, myocarditis, experimental … to prevent the onset of adjuvant-induced
arthritis, EAE, and T1D in rodent studies [43], [44], [45]. Clinically, alefacept, an anti-CD2

Immunomodulatory effect of pentoxifylline in suppressing experimental autoimmune myocarditis

H Takehana, T Inomata, H Niwano, M Nishii… - Circulation …, 2002 - jstage.jst.go.jp
… PTX in the treatment of experimental autoimmune myocarditis (EAM), as a model of the …
Anti-CD2 monoclonal antibodies prevent the induction of experimental autoimmune myocarditis. …

Immunomodulation of experimental autoimmune myocarditis by pentoxifylline

M Milenković, P Milosavljević… - Arhiv za …, 2004 - farfar.pharmacy.bg.ac.rs
… Murine monoclonal antibodies specific for different rat … the first 6 days after induction
EAM (early treatment group); … the early PTX treatment prevented the disease development, …